Table 1.

Clinical characteristics of family members with the R25C-PLN mutation

Pedigree position	DCM	Age of diagnosis, years	LVEDD, mm (Z-score)	LVEF, %	ECG/Arrhythmia	Comment
II.3	Yes	71	60 (4.1)	35	AF, PVCs, LBBB, ICD	HF
III.1	Yes	53	58 (3.4)	40	AF, 1AVB, VT, ICD	HF
III.2	Yes	47	72 (4.85)	28	AF, RBBB, PM/ICD VT, SCD	Heart transplant at 58 years
III.3	Yes	45	59.6 (3.99)	17	NSVT, PM/ICD	HF

LVEDD, left-ventricular end-diastolic dimension by echocardiography; Z-score, number of standard deviations of the LVEDD above the population mean; EF, left-ventricular ejection fraction; AF, atrial fibrillation; PVCs, premature ventricular contractions; LBBB, left bundle branch block; ICD, implantable cardiac defibrillator; HF, heart failure; 1AVB, first-degree atrioventricular block; VT, ventricular tachycardia; RBBB, right bundle branch block; PM, pacemaker; SCD, sudden cardiac death; NSVT, non-sustained ventricular tachycardia.