Table 1.
Novel SNPs and their spatial interactions.
| SNP |
Spatially linked locus |
||||||
|---|---|---|---|---|---|---|---|
| SNP (rs) | Position (Chr:bp) | Gene | Reference | Position | Genes | Disease association | Reference |
| (i) | |||||||
| 16860235 | 3:185512361 | IGF2BP2 | (1) | 15q21.3 | LIPC and HDLCQ12 | Fat metabolism | (13), N |
| 1169288 | 12:120978847 | HNF1A | (5) | 10q11.21 | PRKG1 | Energy metabolism, cellular aging, and late onset diseases (e.g., cardiovascular) | (16, 17), N |
| (ii) | |||||||
| 2001844 | 8:126478745 | N/A (40 kb) | (5) | 8q24.13 | TRIB1 | Lipid metabolism and serum lipid levels | (13), N |
| 6909 | 19:19619542 | GATAD2A | (2) | 19p12 | NCAN | Serum lipid levels and coronary heart disease | N |
| 2p11.2 | IMMT, ST3GAL5, MAT2A, FABP1 | Insulin signaling, insulin growth factor and fatty acid metabolism | N | ||||
| 7798124 | 7:15055616 | N/A (>40 kb) | (1) | 7p21.1 | AGMO (TMEM195) | Decreased glucose-stimulated insulin response, type 2 diabetes | N |
| 3p12.2 | Glycogen storage disease IV | N, G | |||||
| 7168849 | 15:90346227 | ANPEP | (1) | 15q26.1 | IDDM3 | Insulin-dependent diabetes | N |
| 3q22.1 | TF, TOPBP1, NPHP3 | Iron homeostasis, pulmonary arterial hypertension, adrenal-hepatic-pancreatic dysplasia. | N, G | ||||
| 7111 | 15:90373873 | AP3S2 | (1) | 9p31.2 | IGFBPL1, IGFBPRP4 | Insulin growth factor binding protein genes | N |
| 11755566 | 6:38116669 | ZFAND3 | (1) | 6q22 | FIQTL1 | Altered fasting insulin levels | N |
| (iii) | |||||||
| 3741530 | 12:123469647 | ABCB9 PITPNM2 | (3) | 12q24 | SBNO1 | Coronary artery disease and hypertension | N |
| 2q34 | SPAG16 | Childhood obesity in Hispanics | N | ||||
| 2p24 | RAD51AP2 | Hypertension in Japanese | N | ||||
| 703977 | 10:0944230 | ZMIZ1 | (1) | 10q22.3 | DUPD1 | South Asia populations energy metabolism and weight in females | (18), N |
| 11683087 | 2:227586606 | IRS1 | (7) | 14q23.3-q24.1 | TMEM229B/PLEKHH1 | Susceptibility to insulin resistance T2D GWAS | N |
N/A, not applicable, distance to closest gene in brackets. N, NIH GWAS Catalog and NIH Gene Database; G, Genecards and Uniprot.