Table 3. Summary of the CNVs for which frequency was significantly different among AD+P, AD intermediate P and AD−P.
| CNV type | Chr | Position (hg18) | Length (bp) | # of SNPs | AD+P n=440 (freq) | AD int P n=593 (freq) | AD−P n=136 (freq) | Odds ratio | P-value | FDR | Gene |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dup | |||||||||||
| 9 | 130 459 243–130 492 493 | 33 250 | 16 | 27 (6.1%) | 95 (16.0%) | 24 (17.6%) | 0.443 | 1.95E−06 | 6.81E−04 | SET | |
| 14 | 104 694 657–104 708 792 | 14 135 | 17 | 21 (4.8%) | 105 (17.7%) | 19 (14.0%) | 0.429 | 5.01E−07 | 2.29E−04 | JAG2 | |
| 16 | 87 124 205–87 132 458 | 8253 | 15 | 31 (7.0%) | 127 (21.4%) | 25 (18.4%) | 0.443 | 2.13E−07 | 1.95E−04 | ZFPM1 | |
| 17 | 20 651–31 497 | 10 846 | 26 | 33 (7.5%) | 129 (21.8%) | 20 (14.7%) | 0.493 | 4.25E−06 | 1.24E−03 | — | |
| 19 | 1 411 473–1 424 152 | 12 679 | 18 | 43 (9.8%) | 172 (29.0%) | 33 (24.3%) | 0.42 | 7.20E−10 | 8.97E−07 | APC2 | |
| Del | |||||||||||
| 4 | 162 098 516–162 104 179 | 11 657 | 14 | 115 (26.1%) | 116 (19.6%) | 17 (12.5%) | 1.723 | 8.27E−05 | NSa | — | |
| 9 | 17 259 437–17 388 404 | 128 967 | 34 | 7 (1.6%) | 0 (0.0%) | 0 (0.0%) | ∞ | 8.87E−04 | NSa | CNTLN | |
Abbreviations: AD, Alzheimer's disease; FDR, false discovery rate; NS, not significant; P, psychosis.
a
P>0.05.