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. 2015 Jun 9;5(6):e577. doi: 10.1038/tp.2015.75

Figure 1.

Figure 1

Rapgef6 deletion impairs contextual and cued fear conditioning, implying amygdala dysfunction. (a) Contextual fear conditioning had a significant effect of genotype (P=0.016) but not test time (P=0.09) with HOM mice freezing less in the original context at the second, fourth and fifth minutes (P<0.05). (b) Averaged contextual fear also had a significant effect of genotype (P=0.016), with HOM mice freezing significantly less than WT (P<0.05). (c) In the novel context, there was a significant effect of genotype (P=0.03) with HET and HOM mice freezing less than WT in the final minute (P<0.05). (d) Averaged novel context was also significantly affected by genotype (P=0.03) with no post hoc comparisons significant. (e) Cued fear conditioning had a significant effect of genotype (P=0.003). HOM mice froze less than WT at each time point (P<0.05). (f) Averaged cued fear was also significantly affected by genotype (P=0.003) with HOM mice freezing less than HET (P<0.05) and WT (P<0.01). *P<0.05, **P<0.01 and ***P<0.001. HET, heterozygous; HOM, homozygous; WT, wild type.