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. 2015 Jun 9;5(6):e577. doi: 10.1038/tp.2015.75

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Copyright © 2015 Macmillan Publishers Limited

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Rapgef6 deletion impairs amygdala neural activation during fear conditioning. (a) Basolateral nucleus of the amygdala cFOS staining was significantly increased in HOM mice over WT at baseline (P<0.01). WT cFOS significantly increased after fear conditioning (P<0.05), but no other genotype had an increase in cFOS. Scale bar, 200 μm for all micrographs. (b) Lateral nucleus cFOS staining was significantly affected by fear conditioning (P<0.0001). Post hoc comparisons of genotype-specific effects within and between fear conditioning groups were not significant (P>0.05). (c) Central nucleus cFOS staining was not significantly affected by genotype or fear conditioning. *P<0.05, **P<0.01 and ***P<0.001. HET, heterozygous; HOM, homozygous; WT, wild type.