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. 2015 Jun 23;5(6):e587. doi: 10.1038/tp.2015.77

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Representative P50 event-related potentials illustrating P50 gating deficits in schizophrenia. (a) In a healthy subject (left pair of traces), the brain inhibits its response to the second (S2) of a pair of repeated stimuli. A patient with schizophrenia (right pair of traces) is unable to inhibit response to this stimulus. (b) This effect can be normalized by treatments that increase response to the first stimulus (S1, left pair of traces) or decrease response to second stimulus (S2, right pair of traces). S1, first stimulus; S2, second stimulus; SZ, schizophrenia.