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. 2015 Jun 16;5(6):e584. doi: 10.1038/tp.2015.78

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The relationship between plasma MAPKAPK5 levels and 10-year change in CANTAB-PAL in TwinsUK. Scatterplot comparing (a) plasma MAPKAPK5 levels and 10-year change in CANTAB-PAL in TwinsUK, or (b) MZ twin differences in both. Points are coloured by APOE E4 data. (a) GEEs covarying for age and taking into account twin relatedness show an association between plasma MAPKAPK5 and the 10-year change in CANTAB-PAL (β=0.48, Q=0.0059). (b) Linear regression covarying for age shows an association between plasma MAPKAPK5 and the 10-year change in CANTAB-PAL in the MZ twin difference context (β=0.55, P=0.030). CANTAB-PAL, CANTAB-paired associates learning; GEE, generalised estimation equation; MZ, monozygotic; RFU, relative fluorescence unit.