Table 3. Results of the regression analyses for cognitive domain data.

Cognitive domain	Predictor	N	β	s.e.	t	P	R2 change	F
Episodic memory	Age	401	−0.04	0.01	−6.25	<0.01
	CR	401	0.05	0.02	2.56	0.01
	Gender	401	0.53	0.10	5.40	<0.001
	APOE	401	−0.06	0.10	−0.57	0.57
	BDNF	401	−0.01	0.10	−0.09	0.93
	CR × APOE	401	−0.01	0.04	−0.32	0.75	0.00	0.10
	CR × BDNF	401	−0.06	0.04	−1.40	0.16	0.00	1.97
Working memory	Age	401	−0.05	0.01	−7.18	<0.01
	CR	401	0.07	0.02	3.26	<0.01
	Gender	401	−0.10	0.10	−1.03	0.31
	APOE	401	0.06	0.10	0.64	0.52
	BDNF	401	−0.12	0.10	−1.19	0.24
	CR × APOE	401	0.04	0.04	0.99	0.33	0.00	0.97
	CR × BDNF	401	0.04	0.04	0.98	0.33	0.00	0.96
Executive function	Age	397	−0.06	0.01	−9.25	<0.01
	CR	397	0.11	0.02	5.40	<0.01
	Gender	397	0.19	0.10	2.01	0.045
	APOE	397	0.13	0.10	1.36	0.21
	BDNF	397	−0.00	0.09	−0.05	0.96
	CR × APOE	397	0.02	0.04	0.41	0.68	0.00	0.17
	CR × BDNF	397	−0.08	0.04	−1.97	0.049	0.01	3.88
Language processing	Age	415	0.00	0.01	0.36	0.62
	CR	415	0.16	0.02	8.00	<0.01
	Gender	415	−0.16	0.10	−1.67	0.10
	APOE	415	0.08	0.10	0.79	0.43
	BDNF	415	−0.07	0.10	−0.78	0.44
	CR × APOE	415	0.03	0.04	0.60	0.55	0.00	0.36
	CR × BDNF	415	−0.07	0.04	−1.35	0.18	0.00	1.82

Abbreviations: APOE, apolipoprotein E; BDNF, brain-derived neurotrophic factor; CR, cognitive reserve.

Note: APOE and BDNF main and interaction effects were tested in separate models.

Bold values are statistically significant values with P<0.05.