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. 2015 May 14;100(7):2709–2717. doi: 10.1210/jc.2014-4342

Table 3.

Relationship between GH 14-Day AUC/42-Day AUC and 7-Year Cognitive Outcomes

Cognitive Outcomes 14-Day AUC (Unadjusted; n = 83)
 14-Day AUC (Adjusted; n = 79)
 42-Day AUC (Unadjusted; n = 83)
 42-Day AUC (Adjusted; n = 79)
β R2 (%) P β sr2 (%) P β R2 (%) P β sr2 (%) P
General intellectual ability
    FSIQ −0.13 1.6 .263 −0.13 1.3 .221 −0.13 1.7 .223 −0.14 1.7 .146
Language
    General language ability −0.11 1.2 .288 −0.09 0.6 .354 −0.11 1.3 .325 −0.16 2.2 .119
Verbal working memory, learning, and memory
    Immediate verbal memory 0.02 0.02 .870 0.03 0.08 .780 0.04 0.2 .687 −0.03 0.1 .765
    Working memory −0.19 3.5 .045 −0.24 4.4 .025 −0.17 3.1 .097 −0.24 5.1 .030
    Verbal learning −0.03 0.09 .787 −0.07 0.3 .604 −0.03 0.09 .764 −0.12 1.2 .280
    Verbal memory −0.003 <0.001 .969 −0.04 0.1 .690 −0.02 0.03 .869 −0.09 0.7 .355
Spatial working memory, learning, and memory
    Immediate spatial memory 0.003 <0.001 .974 −0.07 0.3 .428 −0.09 0.8 .326 −0.21 3.7 .017
    Spatial learning −0.10 1.0 .404 −0.16 2.0 .181 −0.06 0.3 .567 −0.18 2.7 .062
    Spatial memory −0.14 2.0 .237 −0.22 3.6 .086 −0.12 1.4 .255 −0.24 5.1 .026
Attention and executive functioning
    Selective attention −0.009 0.01 .931 0.006 <0.001 .955 −0.07 0.5 .527 −0.11 1.1 .333
    Sustained attention −0.18 3.3 .147 −0.12 1.2 .336 −0.16 2.4 .202 −0.21 3.9 .104
    Shifting attention −0.26 6.8 .010 −0.31 7.2 .017 −0.19 3.6 .061 −0.16 2.2 .175
    Divided attention −0.19 3.5 .075 −0.21 3.3 .122 −0.14 2.0 .182 −0.17 2.6 .154
    Planning 0.003 <0.001 .972 −0.05 0.2 .648 −0.08 0.6 .477 −0.16 2.1 .139
Speed of information processing and reaction time
    Simple reaction timea −0.03 0.07 .842 −0.08 0.5 .480 0.03 0.1 .794 0.01 0.02 .905
    Complex reaction timea 0.11 1.2 .238 0.05 0.2 .618 0.08 0.6 .490 0.02 0.03 .878

Covariates for adjusted analyses included gestational age, birth weight z score, sex, social risk, marker of illness, and neonatal brain injury.

Some sample sizes are less than the total sample due to missing data.

Bold values denote statistical significance (P < .05).

a

Task is reverse scored where higher scores signify a slower reaction time.