Table 4.

Relationship between GH 14-Day AUC/42-Day AUC and 7-Year Imaging Outcomes

Imaging Outcomes	14-Day AUC (Unadjusted; n = 52)			14-Day AUC (Adjusted; n = 52)			42-Day AUC (Unadjusted; n = 52)			42-Day AUC (Adjusted; n = 52)
	β	R2 (%)	P	β	sr2 (%)	P	β	R2 (%)	P	β	sr2 (%)	P
Total brain tissue	−0.02	0.04	.881	0.04	0.09	.743	−0.19	3.7	.261	−0.07	0.4	.491
Cortical gray matter	0.02	0.07	.837	0.09	0.5	.529	−0.15	2.2	.376	−0.03	0.08	.797
Cortical white matter	−0.04	0.2	.746	0.03	0.09	.788	−0.21	4.3	.201	−0.09	0.7	.392
Cerebellum	0.13	1.7	.507	0.17	2.0	.191	−0.05	0.2	.803	0.08	0.5	.505
Pituitary	−0.04	0.2	.639	0.06	0.3	.509	−0.07	0.5	.452	0.04	0.1	.665
Thalamus	0.13	1.7	.438	0.06	0.3	.613	−0.03	0.09	.851	−0.04	0.1	.729
Basal ganglia	0.12	1.4	.425	0.21	3.1	.109	−0.02	0.02	.910	0.08	0.6	.400
Hippocampus	0.10	1.0	.579	0.20	3.0	.127	−0.05	0.2	.804	0.04	0.2	.747
Amygdala	0.20	4.1	.216	0.31	6.6	.002	0.09	0.8	.558	0.23	4.7	.031

Covariates for adjusted analyses included gestational age, birth weight z score, sex, marker of illness, and neonatal brain injury.

Some sample sizes are less than the total sample due to missing data.

Bold values denote statistical significance (P < .05).