Figure 2.

Expected surgical histopathology outcomes in thyroid nodules with AUS/FLUS or FN/SFN cytopathology after diagnostic surgery or after preoperative molecular testing. The size of each box and the associated percentages represent the expected proportions of benign/malignant outcomes (white/black boxes) or molecular results (white/dark gray boxes) at 32% (A) or 24% (B) thyroid cancer prevalence. The residual risk of malignancy (ROM) in nodules with negative/benign molecular results is [1-NPV] and the ROM in nodules with positive/malignant molecular results is PPV. The rate of unnecessary or potentially avoidable surgeries is the proportion of surgeries performed on nodules subsequently classified as benign by surgical histology. Abbreviations: B, benign; Mal, malignant.