Table 3.
Baseline |
2 Mo |
14 Mo |
P value |
|||||
---|---|---|---|---|---|---|---|---|
CON | LIPO | CON | LIPO | CON | LIPO | Time | Time × group | |
Meal-derived fatty acid trafficking (relative) | ||||||||
Oxidized, % | 26 ± 8 | 24 ± 6 | 25 ± 6 | 24 ± 6 | 20 ± 4 | 20 ± 3 | 0.001* | 0.674 |
Upper body SAT, % | 17 ± 13 | 11 ± 4 | 13 ± 5 | 13 ± 9 | 18 ± 5 | 21 ± 6 | 0.031* | 0.154 |
Lower body SAT, % | 10 ± 7.2 | 12 ± 6 | 12 ± 11 | 8 ± 9 | 16 ± 6 | 16 ± 5 | 0.025* | 0.457 |
Ectopic, % | 45 ± 23 | 56 ± 9 | 53 ± 20 | 54 ± 15 | 47 ± 7 | 43 ± 8 | 0.117 | 0.164 |
Meal-derived fatty acid uptake (absolute) | ||||||||
Upper body SAT (mg meal TG in trunk FM × 103) | 4.3 ± 3.1 | 2.8 ± 1.0 | 3.2 ± 1.3 | 3.5 ± 2.6 | 3.8 ± 1.3 | 4.4 ± 1.3 | 0.415 | 0.211 |
Lower body SAT (mg meal TG in leg FM × 103) | 2.4 ± 1.9 | 3.1 ± 1.6 | 3.0 ± 2.8 | 2.0 ± 2.1 | 4.0 ± 1.3 | 3.9 ± 1.4 | 0.026* | 0.373 |
LPL activity | ||||||||
Abdominal SAT | ||||||||
nmol·min−1·g−1 | 11.8 ± 10.0 | 17.3 ± 11.1 | 15.0 ± 5.9 | 21.3 ± 9.3 | 16.9 ± 12.7 | 12.4 ± 6.4 | 0.469 | 0.199 |
nmol·min−1·106 cells | 0.16 ± 0.15 | 0.21 ± 0.21 | 0.18 ± 0.09 | 0.21 ± 0.18 | 0.25 ± 0.21 | 0.10 ± 0.06 | 0.940 | 0.250 |
Femoral SAT | ||||||||
nmol·min−1·g−1 | 27.1 ± 19.4 | 48.6 ± 8.5 | 33.3 ± 29.9 | 19.8 ± 8.8 | 37.6 ± 18.1 | 21.8 ± 15.9 | 0.152 | 0.005* |
nmol·min−1·106 cells | 0.60 ± 0.50 | 0.65 ± 0.31 | 0.51 ± 0.51 | 0.27 ± 0.23 | 0.69 ± 0.64 | 0.13 ± 0.07 | 0.209 | 0.114 |
Values are means ± SD.
LPL, lipoprotein lipase; SAT, subcutaneous adipose tissue. P value for an overall effect of time and time-by-group interaction (general linear model, repeated measures).
P < 0.05.