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. 2015 Jul 3;5:11820. doi: 10.1038/srep11820

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Copyright © 2015, Macmillan Publishers Limited

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Panel a shows the CD8⁺ IFNγ⁺ responses measured in the spleen and the liver two weeks post-MVA boost for both PfLSA1 and PfLSAP2 vaccinated BALB/c mice, expressed as the percentage of total CD8⁺ cells. Individual data points and the median of three to six biological replicates are shown. Liver mononuclear cells were also stained with the markers CD62l and CD127 to calculate the percentage of effector memory (CD62l⁻ CD127⁺) and central memory (CD62l⁺ CD127⁺) subsets. The gating strategy used to identify the populations is shown in panel b; gating was first performed on CD8⁺ cells, where a clear central memory population can be seen (CD62l⁺ CD127⁺). Antigen-specific cells were then selected based on secretion of IFNγ and a representative population is shown. The graph shows the percentage effector memory population in the liver.