Table 3. Univariate analysis of factors associated with hepatic steatosis stratified by body mass index.
| BMI<24 kg/m2 |
BMI24-27 kg/m2 |
BMI>27 kg/m2 |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Steatosis (-) (n = 282) | Steatosis (+) (n = 144) | P value | Steatosis (–) (n = 166) | Steatosis (+) (n = 173) | P value | Steatosis (–) (n = 115) | Steatosis (+) (n = 138) | P value | |
| Age (years, mean + SD) | 50.4 + 12.4 | 52.4 + 12.0 | 0.12 | 51.6 + 11.2 | 54.0 + 9.2 | 0.03 | 51.4 + 11.1 | 52.3 + 10.7 | 0.51 |
| Male gender, n (%) | 147 (52.1) | 80 (55.6) | 0.50 | 101 (60.8) | 97 (56.1) | 0.37 | 70 (60.9) | 81 (58.7) | 0.73 |
| Diabetes, n (%) | 33 (11.7) | 18 (12.5) | 0.81 | 16 (9.6) | 35 (20.2) | 0.006 | 23 (20.0) | 33 (23.9) | 0.46 |
| Platelet count (x103u/L, mean + SD) | 166 + 56 | 161 + 57 | 0.39 | 170 + 56 | 158 + 56 | 0.04 | 155 + 55 | 169 + 65 | 0.07 |
| GOT (IU/L,mean + SD ) | 105 + 66 | 101 + 50 | 0.51 | 104 + 70 | 104 + 56 | 0.98 | 102 + 63 | 106 + 57 | 0.56 |
| GPT (IU/L,mean + SD) | 160 + 112 | 152 + 76 | 0.43 | 160 + 115 | 154 + 97 | 0.61 | 155 + 119 | 160 + 83 | 0.69 |
| Ferritin(ng/ml, mean + SD) | 408 + 632 | 363 + 306 | 0.32 | 408 + 542 | 445 + 351 | 0.45 | 366 + 317 | 431 + 368 | 0.14 |
| r-GT (U/L,mean + SD) | 56.4 + 61.4 | 63.5 + 43.3 | <0.001 | 65.4 + 60.6 | 74.1 + 58.4 | 0.035 | 72.2 + 66.4 | 82.9 + 83.6 | 0.04 |
| HCV genotype 1, n/N (%) | 170/282 (60.3) | 80/142 (56.3) | 0.44 | 107/166 (64.5) | 95/172 (55.2) | 0.08 | 67/114 (58.8) | 85/136 (62.5) | 0.55 |
| HCV RNA(log IU/mL, mean + SD) | 5.28 + 1.05 | 5.30 + 0.90 | 0.84 | 5.42 + 1.05 | 5.36 + 0.92 | 0.56 | 5.53 + 0.93 | 5.52 + 0.92 | 0.92 |
| HBsAg (+), n (%) | 33 (11.7) | 8 (5.6) | 0.04 | 14 (8.4) | 15 (8.7) | 0.94 | 6 (5.2) | 14 (10.1) | 0.15 |
| F34, n (%) | 66 (23.4) | 38 (26.4) | 0.50 | 46 (27.7) | 61 (35.3) | 0.14 | 50 (43.5) | 47 (34.1) | 0.13 |
| PNPLA3 rs738409 | |||||||||
| CC/CG/GG, n (%) | 117 (41.5)/ 147 (52.1)/ 18 (6.4) | 43 (29.9)/ 73 (50.7)/ 28 (19.4) | <0.001 | 74 (44.6)/ 78 (47.0)/ 14 (8.4) | 75 (43.4)/72 (41.6)/26 (15.0) | 0.16 | 56 (48.7)/ 47(40.9)/ 12 (10.4) | 57 (41.3)/ 60 (43.5)/ 21 (15.2) | 0.37 |
| Recessive model GG, n (%) | 18 (6.4) | 28 (19.4) | <0.001 | 14 (8.4) | 26 (15.0) | 0.06 | 12(10.4) | 21 (15.2) | 0.26 |
| Dominant model GG+GC, n (%) | 165 (58.5) | 101 (70.1) | 0.02 | 92 (55.4) | 98 (56.6) | 0.82 | 59 (51.3) | 81 (58.7) | 0.24 |
Note: BMI: body mass index; rGT: r-glutamyltransferase; AST: alanine aminotransferase; ALT: aspartate aminotransferase; HBsAg: hepatitis B surface antigen; PNPLA3: patatin-like phospholipase domain-containing 3.