Table 1.

Summary of works that found out a strong correlation between cerebellar abnormalities and cognitive impairment as measured by neuropsychological tests. For a list of abbreviation see Abbreviations section.

Article	MS Phenotype	No. of Subjects	Imaging Method	MRI Features	Neuropsychological Findings	Neuroimaging Findings
Valentino et al., 2009	RR-MSc	21	Semi-automated morhpometry	Cerebellar and cortical TLL	RR-MSc: Deficits in SDMT and COWAT with respect to RR-MSnc	RR-MSc: No significant correlation between cognitive impairment and TLL
	RR-MSnc	21
Cerasa et al., 2012	RR-MSc	12	Semi-automated morhpometry/fMRI task	Cerebellar TLL and volume	RR-MSc: Deficits in SDMT, ST and WLG with respect to controls	RR-MSc: Cerebellar TLL correlated with fMRI activity of the superior parietal lobule during PVSAT
	RR-MSnc	15
	Controls	16
Cerasa et al., 2013	RR-MSc	12	Semi-automated morhpometry/VBM	Cerebellar TLL and GM volume	RR-MSc: Deficits in SDMT, COWAT and ROCFT with respect to RR-MSnc and controls	RR-MSc: GM volume in the dorsolateral prefrontal cortex correlated with SDMT; GM volume in superior temporal gyrus correlated with COWAT
	RR-MSnc	14
	Controls	20
Damasceno et al., 2014	RR-MS	42	Semi-automated morhpometry/FreeSurfer	Cerebellar GM/WM volume, intracortical/leukocortical lesions (nr. and volume)	RR-MS: deficits in SDMT and PASAT with respect to controls	RR-MS: Cerebellar intracortical lesions associated with SDMT, Cerebellar leukocortical lesions associated with PASAT
	Controls	30
Rocca et al., 2014	RR-MS	121	fMRI connectivity	Global and regional network properties, hubs	–	RR-MS: PASAT correlated with global network features, with absence of additional hubs in Lobule VII of right cerebellum, and with a decrease of nodal degree in right cerebellum
	B-MS	45
	SP-MS	80
Romascano et al., 2014	RR-MS	28	Automated morhpometry/fMRI connectivity	Cerebellar lesion (nr. and volume), CPN parameters: T1 rt, T2 rt, MTR, GFA	RR-MS: No cognitive deficit	RR-MS: T1 rt, T2 rt, GFA associated with the SRT-LTS, GFA correlated SRT-CLTR and SDMT, T2 rt correlated with SPART-D
	Controls	26
Weier et al., 2014	RR-MSc	120	Semi-automated morhpometry/SIENAX	TCV, CGV, CWV	RR-MSc: Deficits in SDMT and PASAT with respect to RR-MSnc	RR-MSc: TCV correlated with SDMT, cerebellar T1 lesion volume significant predictor of PASAT
	RR-MSnc	52
Deppe et al., 2015	RR-MS	68	DTI	Cerebellar FA, AD, MD, RD	–	RR-MS: Cerebellar FA correlated with motor disability scale (EDSS)
	Controls	26