Table 1.

Over-represented biological functions analysis in differentially expressed genes in DIO mice treated with pioglitazone for 38 days.

	Biological Function	Gene Count	Benjamini	Fold Enrichment
Upregulated in Progressors	lipid metabolic process	33	6.50 × 10−7	3.6
	cellular ketone metabolic process	27	9.00 × 10−7	4.2
	carboxylic acid metabolic process	26	1.70 × 10−6	4.1
	oxoacid metabolic process	26	1.70 × 10−6	4.1
	organic acid metabolic process	26	1.30 × 10−6	4.1
	monocarboxylic acid metabolic process	19	4.00 × 10−6	5.4
	cellular lipid metabolic process	25	4.50 × 10−6	3.9
	fatty acid metabolic process	15	2.70 × 10−5	6.2
	oxidation reduction	25	1.30 × 10–3	2.8
	lipid biosynthetic process	15	3.60 × 10−3	4
Downregulated in Progressors	acute inflammatory response	7	7.60 × 10−4	20.1
	acute-phase response	5	2.50 × 10−3	38.8
	inflammatory response	8	9.70 × 10−3	8.3
	defense response	9	9.00 × 10−2	4.7
	response to wounding	8	8.10 × 10−2	5.4
	response to external stimulus	10	1.40 × 10−1	3.6
	fat cell differentiation	4	1.90 × 10−1	15.3
	localization	21	3.40 × 10−1	1.8
	transport	19	3.90 × 10−1	1.9
	brown fat cell differentiation	3	3.60 × 10−1	24.1

The over-represented top 10 biological functions regulated in differentially expressed genes are listed.