Table 1.
Chemical structures and bioactivity values of the imidazopyridines in the current study.
| Compound | General Structure | Substituents | IC50 (nM) | pIC50 |
|---|---|---|---|---|
| 1 |  |
- | 42 | 7.377 |
| 2 b |  |
- | 18 | 7.745 |
| 3 |  |
- | 247 | 6.607 |
| 4 a |  |
H | 61 | 7.215 |
| 5 | Me | 40 | 7.398 | |
| 6 | Et | 59 | 7.229 | |
| 7 a | i-Pr | 60 | 7.222 | |
| 8 | t-Bu | 69 | 7.161 | |
| 9 b | Cyclobutyl | 31 | 7.509 | |
| 10 | 4-Piperidine | 107 | 6.971 | |
| 11 | 3-Piperidine | 167 | 6.777 | |
| 12 |  |
H | 3.6 | 8.444 |
| 13 | 4-F | 4.4 | 8.357 | |
| 14 a | 4-Cl | 2.2 | 8.658 | |
| 15 | 4-Br | 2.2 | 8.658 | |
| 16 a | 3-F | 3.1 | 8.509 | |
| 17 | 3-Cl | 1.1 | 8.959 | |
| 18 b | 3-Br | 0.76 | 9.119 | |
| 19 | 2-F | 8.0 | 8.097 | |
| 20 | 2-Cl | 27 | 7.569 | |
| 21 a | 2-Br | 27 | 7.569 | |
| 22 | 3,4-di-F | 3.4 | 8.469 | |
| 23 | 3,4-di-Cl | 1.5 | 8.824 | |
| 24 b | 4-MeO | 1.1 | 8.959 | |
| 25 a | 4-Me | 1.3 | 8.886 | |
| 26 b | 4-CF3 | 1.4 | 8.854 | |
| 27 | 4-CF3O | 2.4 | 8.620 | |
| 28 a | 4-CN | 2.7 | 8.569 | |
| 29 | 4-MeSO2 | 1.4 | 8.854 | |
| 30 | 3-MeO | 1.2 | 8.921 | |
| 31 b | 3-CF3 | 1.0 | 9.000 | |
| 32 a | 4-Pyridyl | 3.2 | 8.495 | |
| 33 | 3-Pyridyl | 3.0 | 8.523 | |
| 34 b |  |
H | 1.0 | 9.000 |
| 35 a | 4-F | 1.1 | 8.959 | |
| 36 | 4-Cl | 2.4 | 8.620 | |
| 37 b |  |
H | 4.6 | 8.337 |
| 38 | 4-F | 11 | 7.959 | |
| 39 a | 4-Cl | 8.2 | 8.086 |
a Test set compounds; b Compounds used to generate pharmacophore models.