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. 2015 Jun 3;16(6):12482–12498. doi: 10.3390/ijms160612482

Figure 6.

Figure 6

Si-CSE or ERK inhibitor partly abolishes the anti-apoptotic effects of UII on H2O2-treated-cardiomyocytes. (A) Representative images of TUNEL staining in cultured cardiomyocytes. Bar = 25 μm; (B) Quantitative analysis of TUNEL staining in cultured cardiomyocytes transfected with si-scramble or si-CSE for 48 h, treated with UII (0.1 μM) or PBS for 30 min, then exposed to 100 μM H2O2 for 24 h. Values are mean ± SEM. * p < 0.05, ** p < 0.01, UII + si-scram vs. Si-scramb or UII + si-CSE vs. Si-CSE. # p < 0.05. UII + si-CSE vs. UII + si-scram; (C) Quantitative analysis of TUNEL staining in cultured cardiomyocytes treated with DMSO or U0126 with or without UII for 30 min and exposed to 100 μM H2O2 for 24 h. Values are mean ± SEM. * p < 0.05, ** p < 0.01, UII vs. DMSO or UII + U0126 vs. UII + DMSO. ## p < 0.01 UII + U0126 vs. UII + DMSO. All experiments were repeated independently at least three times.