Table 4.
Association of Vitamin D receptor (VDR) BsmI gene polymorphism with metabolic parameters (Acrelândia, Brazil, 2007–2009).
| VDR BsmI Gene Polymorphism | |||||||
|---|---|---|---|---|---|---|---|
| Variables | Adjusted β-Coefficient a | 95% CI | R2 | Fully Adjusted β-Coefficient b | 95% CI | R2 | p for Interaction between BsmI x 25-Hydroxyvitamin D |
| Insulin concentration | 0.095 | −0.028; 0.218 | 0.168 | 0.104 | −0.008; 0.216 | 0.319 | 0.323 |
| HOMA-IR | 0.110 | −0.020; 0.242 | 0.170 | 0.122 | 0.002; 0.243 | 0.316 | 0.336 |
| Glucose (mg/dL) | 1.502 | 0.064; 2.940 | 0.101 | 1.696 | 0.259; 3.133 | 0.113 | 0.591 |
| Systolic blood pressure (mmHg) | −0.667 | −2.421; 1.085 | 0.020 | −0.646 | −2.413; 1.119 | 0.021 | 0.625 |
| Diastolic blood pressure (mmHg) | −0.180 | −1.402; 1.042 | 0.012 | −0.125 | −1.362; 1.111 | 0.003 | 0.678 |
| 25-hydroxyvitamin D (nmol/L) | 0.007 | −0.059; 0.073 | 0.012 | 0.100 | −0.056; 0.076 | 0.001 | -- |
VDR BsmI polymorphism was coded additively for the minor allele. HOMA-IR: homeostasis model assessment index of insulin resistance. p values were calculated using linear regression models. Insulin levels, HOMA-IR and 25-hydroxyvitamin D were log-transformed before analysis. a Model was adjusted for age, sex and race/ethnicity; b Model was adjusted for age, sex, race/ethnicity, BMI-for-age Z-scores, Tanner stage and baseline household wealth; models for systolic and diastolic blood pressure were additionally adjusted for the child’s height.