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. 2015 Jun 19;16(6):14086–14097. doi: 10.3390/ijms160614086

Figure 1.

Figure 1

Structure of hepatoma-derived growth factor (HDGF). HDGF protein contains 240 amino acids. The N-terminal region of HDGF protein is highly homologous to that of HDGF-related proteins, and the well-conserved N-terminal amino acid sequence (approximately 100 amino acids) is represented as the HATH (homologous to the amino terminus of HDGF) domain. HDGF has two putative nuclear localization signals (NLSs). The first NLS is a basic amino acid-rich region (75 KPNKRK 80; basic residues underlined) in the HATH domain (NLS1), and HDGF protein also contains a basic motif (155 KRRAGLLEDSPKRPK 170; basic residues underlined) in the gene-specific region (NLS2).