Table 4.

CTs exhibiting radial repositioning in activated lymphocytes compared to resting lymphocytes

2D repositioning
Male Subject		Female Subject
CTs	Movement	CTs	Movement
1, 6, 14, 16, 20	Less interior	1, 15, 19	Less interior
4, 5, 9	Interior to intermediate	11	Interior to intermediate
2	Intermediate to periphery	7	Interior to periphery
X	Intermediate to interior	-	-
3D repositioning
Male Subject		Female Subject
CTs	Movement	CTs	Movement
11, 14, 15, 16, 17, 19	More peripheral	11, 16, 19, X	More peripheral

CTs involved in statistical significant radial repositioning between resting and activated lymphocytes in both the male and female subject, as determined by 2D and 3D approaches. 2D radial repositioning was determined using the χ ² goodness-of-fit test (p < 0.05). The direction of the repositioning movement was determined by comparing the radial distribution of CTs in each subject in resting and activated lymphocytes (Fig. 1). 3D radial repositioning was determined using the two-tailed, paired t-test (p < 0.05). The direction of the repositioning movement was determined based on the distance to the nuclear edge in activated lymphocytes compared to resting lymphocytes