Fig. 2.

Results of post-hoc analysis. (a1) For the left hippocampus, T2DM patients with poorly controlled cholesterol had decreased functional connectivity in the left insula, left MFG, and bilateral IPL and increased connectivity was seen in the bilateral calcarine and left lingual gyrus compared with healthy controls; (a2) For the left hippocampus, T2DM patients with poorly controlled cholesterol had decreased connectivity in the left MFG and increased connectivity in the left lingual gyrus when compared with T2DM patients with target cholesterol; (b1) For the right hippocampus, T2DM patients with poorly controlled cholesterol had decreased connectivity in the left IFG, right MFG, and right IPL and their bilateral calcarine and right lingual had increased functional connectivity compared with the healthy controls; (b2) For the right hippocampus, the poorly controlled cholesterol group showed decreased functional connectivity in the right MFG and increased functional connectivity in the right precuneus compared with the target cholesterol group. Thresholds were set at a corrected p < 0.05, determined by Monte Carlo simulation. The left side corresponds to the right hemisphere of the brain