Table 2.
Regions showing significant functional connectivity differences on hippocampus of T2DM patients group compared with healthy controls
| Brain regions | BA | MNI Coordinates x, y, z (mm) | Peak t score | Voxels |
|---|---|---|---|---|
| A. Differences on left hippocampus | ||||
| (I) T2DM patients with poorly controlled cholesterol versus with healthy controls | ||||
| Decreased in T2DM patients with poorly controlled cholesterol | ||||
| L insula | 13 | −33,9,6 | −3.5398 | 131 |
| L middle frontal gyrus | 10 | −36,57,18 | −3.6381 | 291 |
| L inferior parietal lobule | 39/40 | −39,-15,21 | −3.9687 | 220 |
| R inferior parietal lobule | 39/40 | 45,-33,27 | −4.0773 | 130 |
| Increased in T2DM patients with poorly controlled cholesterol | ||||
| L calcarine/ L lingual gyrus | 17 | −9,-57,9 | 4.3789 | 552 |
| R calcarine | 17 | 9,-96,-3 | 3.4545 | 124 |
| (II) T2DM patients with poorly controlled cholesterol versus with T2DM patients with target cholesterol levels | ||||
| Decreased in T2DM patients with poorly controlled cholesterol | ||||
| L middle frontal gyrus | 46 | −27,42,21 | −5.2780 | 195 |
| Increased in T2DM patients with poorly controlled cholesterol | ||||
| L lingual gyrus | 17 | −21,-51,-9 | 3.6838 | 85 |
| B. Differences on right hippocampus | ||||
| (I) T2DM patients with poorly controlled cholesterol versus with healthy controls | ||||
| Decreased in T2DM patients with poorly controlled cholesterol | ||||
| L inferior frontal gyrus | 44/45/46/47 | −39,33,6 | −4.2669 | 198 |
| R middle frontal gyrus | 46 | 36,33,9 | −4.7610 | 1281 |
| R inferior parietal lobule | 40 | 45,-54,39 | −4.5285 | 259 |
| Increased in T2DM patients with poorly controlled cholesterol | ||||
| R calcarine/ R lingual | 17 | 9,-60,0 | 4.3660 | 256 |
| L calcarine | 17 | −9,-57,6 | 3.9207 | 289 |
| (II) T2DM patients with poorly controlled cholesterol versus with patients with target cholesterol levels | ||||
| Decreased in T2DM patients with poorly controlled cholesterol | ||||
| R middle frontal gyrus | 46 | 36,39,27 | −3.9874 | 267 |
| Increased in T2DM patients with poorly controlled cholesterol | ||||
| R precuneus | 7 | 12,-63,21 | 3.4747 | 145 |
A corrected threshold of p < 0.05 determined by Monte Carlo simulation was taken as meaning that there was a significant difference between groups. BA, Brodmann’s area; MNI: Montreal Neurological Institute; L, left; R, right; B = bilateral; cluster size is in mm3