TABLE I.
PROPORTION OF PATIENTS EXPERIENCING INFECTIONS THAT WERE LIFE-THREATENING OR FATAL DURING INDUCTION BY MICROORGANISM*
| Standard N=335 |
Intensive N=343 |
P Value | |
|---|---|---|---|
| All Infections | 56/150 (37.3%) | 147/244 (60.3%) | <0.0001 |
| Bacteria | 48/132 (36.4%) | 118/198 (59.6%) | <0.0001 |
| Gram positive bacteria | 40/107 (37.4%) | 89/159 (56.0) | 0.004 |
| CoNS | 14/41 (34.2%) | 29/53 (54.7%) | 0.061 |
| Viridans group Streptococcus | 12/28 (42.9%) | 38/53 (71.7%) | 0.016 |
| Enterococcus species | 5/15 (33.3%) | 8/24 (33.3%) | 1.000 |
| Staphylococcus aureus | 5/14 (35.7%) | 5/17 (29.4%) | 1.000 |
| Pneumococcus | 0 | 1/3 (33.3%) | NA |
| Other Gram positives | 9/43 (20.9%) | 43/78 (55.1%) | 0.0003 |
| Gram negative bacteria | 10/46 (21.7%) | 52/91 (57.1%) | 0.0001 |
| Pseudomonas species | 3/13 (23.1%) | 19/32 (59.4%) | 0.047 |
| Klebsiella species | 4/12 (33.3%) | 11/21 (52.4%) | 0.469 |
| Escherichiae coli | 1/11 (9.1%) | 8/16 (50.0%) | 0.042 |
| Enterobacter species | 2/5 (40.0%) | 6/13 (46.2%) | 1.000 |
| Citrobacter species | 0 | 1/2 (50.0%) | NA |
| Other Gram negatives | 1/15 (6.7%) | 18/25 (72.0%) | <0.0001 |
| Fungi | 12/33 (36.4%) | 59/94 (62.8%) | 0.014 |
| Yeasts | 8/28 (28.6%) | 32/65 (49.2%) | 0.073 |
| Candida species | 7/25 (28.0%) | 30/60 (50.0%) | 0.092 |
| Non-Candida yeasts | 1/4 (25.0%) | 3/12 (25.0%) | 1.000 |
| Molds | 4/5 (80.0%) | 34/40 (85.0%) | 1.000 |
| Aspergillus species | 1/2 (50.5%) | 26/30 (86.7%) | 0.292 |
| Non-Aspergillus molds | 3/3 (100.0%) | 9/11 (81.8%) | 1.000 |
| Viruses | 2/13 (15.4%) | 17/48 (35.4%) | 0.311 |
Abbreviations: CoNS – coagulase negative Staphylococcus
*
This table illustrates the proportion of infections during induction which were classified as life-threatening or fatal
Note: The sub-categories do not necessarily total the higher level of categories since patients may have more than one type of infection