TABLE II.
PROPORTION OF PATIENTS EXPERIENCING INFECTIONS THAT WERE LIFE-THREATENING OR FATAL DURING INTENSIFICATION BY MICROORGANISM*
| Chemo N=168 |
AutoSCT N=137 |
P Value** |
Allo SCT N=147 |
P Value*** |
|
|---|---|---|---|---|---|
| All Infections | 60/102 (58.8%) |
34/72 (47.2%) |
0.165 | 29/68 (42.7%) |
0.043 |
| Bacteria | 52/95 (54.7%) |
32/69 (46.4%) |
0.343 | 26/59 (44.1%) |
0.246 |
| Gram positive bacteria | 32/63 (50.8%) |
22/47 (46.8%) |
0.704 | 19/40 (47.5%) |
0.840 |
| Coagulase negative Staphylococci | 8/18 (44.4%) |
8/17 (47.1%) |
1.000 | 11/18 (61.1%) |
0.505 |
| Viridans group streptococci | 14//27 (51.9%) |
9/19 (47.4%) |
1.000 | 4/4 (100.0%) | 0.120 |
| Enterococcus species | 0/3 (0%) |
3/6 (50.0%) |
0.464 | 3/5 (60.0%) |
0.196 |
| Staphylococcus aureus | 1/3 (33.3%) |
1/3 (33.3%) |
1.000 | 1/3 (33.3%) |
1.000 |
| Pneumococcus | 0 | 0 | NA | 0/1 (0%) |
NA |
| Other Gram positives | 12/23 (52.2%) |
4/13 (30.8%) |
0.301 | 5/19 (26.3%) |
0.120 |
| Gram negative bacteria | 26/48 (54.2%) |
15/34 (44.1%) |
0.502 | 11/32 (34.4%) |
0.110 |
| Pseudomonas species | 5/11 (45.5%) |
3/12 (25.0%) |
0.400 | 3/10 (30.0%) |
0.659 |
| Klebsiella species | 5/9 (55.6%) |
2/7 (28.6%) |
0.358 | 1 /4 (25.0%) |
0.559 |
| Escherichiae coli | 7/12 (58.3%) |
2/7 (28.6%) |
0.350 | 4/9 (44.4%) |
0.670 |
| Enterobacter species | 2/4 (50.0%) |
1/3 (33.3%) |
1.000 | 1/3 (33.3%) |
1.000 |
| Citrobacter species | 2/3 (66.7%) |
1/1 (100.0%) |
1.000 | 3/5 (60.0%) |
1.000 |
| Other Gram negatives | 7/14 (50.0%) |
6/14 (42.9%) |
1.000 | 3/11 (27.3%) |
0.414 |
| Fungi | 11/16 (68.8%) |
4/11 (36.4%) |
0.130 | 6/9 (66.7%) |
1.000 |
| Yeasts | 6/12 (50.5%) |
2/9 (22.2) |
0.367 | 3/6 (50.0%) |
1.000 |
| Candida species | 5/11 (45.5%) |
1/7 (14.3%) |
0.316 | 3/5 (60.0%) |
1.000 |
| Non-Candida yeasts | 1/1 (100.0%) |
1 /2 (50.0%) |
1.000 | 0/1 (0%) |
1.000 |
| Molds | 5/5 (100.0%) |
2/2 (100.0%) |
NA | 3/3 (100.0%) |
NA |
| Aspergillus species | 3/3 (100.0%) |
0 | NA | 3/3 (100.0%) |
NA |
| Non-Aspergillus Molds | 3/3 (100.0%) |
2/2 (100.0%) |
NA | 0 | NA |
| Viruses | 4/7 (57.1%) |
4/12 (33.3%) |
0.377 | 4/19 (21.1%) |
0.149 |
*
This table illustrates the proportion of infections during induction which were classified as life-threatening or fatal
**
P value is for comparison between autologous stem cell transplantation versus chemotherapy
***
P value is for comparison between allogeneic stem cell transplantation versus chemotherapy
Note: The sub-categories do not necessarily total the higher level of categories since patients may have more than one type of infection