Fig. 4.

Evolution of gut microcirculation variables during the experiment. T-60 min is the beginning of stabilization; T 0 min is the time of bacterial injection. Esmolol is started and hemodynamic stabilization occurs between T 60 and T 180 min after resuscitation is started, and the experiment concluded at T 300 min. ANOVA were performed for each parameter: results are detailed in Table 2. (a) A significant time/group effect was found for the ratio of perfused villi. No significant effect was found for (b) MFI gut or (c) heterogeneity.gut. PV, perfused villi ratio is defined as the ratio of perfused villi under the number of villi visible on the stabilized video; MFI gut, Mean Flow Index of the ileal mucosa; heterogeneity.gut, heterogeneity of the ileal mucosa computed as the difference between the highest and lowest MFI, divided by the mean MFI of all sites at a single time point; GMLDF, Gut microcirculatory laser Doppler blood flow