Table 1.
Group | Old rats, T-current measurementsa | Old rats, Na-current measurementsb | 2-3 months old ratsc | ||||
---|---|---|---|---|---|---|---|
Control | Diabetic 9-13 weeks | Control | Diabetic 9-13 weeks | Control | Diabetic 6-7 weeks | ||
Hypoalgesic | Hyperalgesic | ||||||
Body weight, g | 325 + 25 | 212 + 20d | 323 + 12 | 213 + 14d | 153 + 4 | 128 + 11e | 125 + 8e |
Blood glucose level, mM | 4.5 + 0.3 | 27 + 2f | 4.4 + 0.2 | 28 + 2f | 4.3 + 0.3 | 27 + 2g | 26 + 2g |
n | 4 | 4 | 3 | 3 | 3 | 3 | 3 |
aAnimals (8 months old) were used to measure T-type current and excitability parameters
bAnimals (8 months old) were used to measure Na+ current
cAnimals were used to measure T-type current
dANOVA one way test, p < 0.01
eThere was no significant difference between the group of diabetic hypoalgesic or hyperalgesic and control rats (p > 0.08, ANOVA one way test)
fStudent’s t-test: p < 0.001 for each control and corresponding diabetic group
gStudent’s t-test with α level adjusted with Bonferroni’s procedure: p < 0.005 when diabetic hypoalgesic and hyperalgesic groups were compared with the same control group