FIG. 1.

IL-33 treatment inhibits HBV replication and promotes HBV antibody production in HBV-Tg mice. HBV-Tg mice were injected intraperitoneally with PBS (100 μL/mouse) and IL-33 (2 μg/mouse) twice per week for 4 weeks, respectively. The viral loads, expression of HBV antigens, and production of antibodies were examined. (a) The viral loads of serum HBV DNA examined by qPCR in HBV-Tg mice. (b) The concentrations of serum HBeAg, HBeAb, HBsAg, and HBsAb in HBV-Tg mice. (c) Representative images of HBeAg, HBeAb, HBsAg, and HBsAb staining detected by histological study in liver sections from HBV-Tg mice. The statistical significance of the data was determined using the Mann–Whitney test; P value is shown in each test. HBV, hepatitis B virus; IL-33, interleukin 33; PBS, phosphate buffer saline; qPCR, real-time quantitative PCR detecting system.