Table 5.
Immune Reconstitution after HSCT
| Patient | 1 | 2 | 8 | 9 | 10 | 11 | 12 | 13 | Normal range |
|---|---|---|---|---|---|---|---|---|---|
| Absolute lymphocyte count (cells/μl) | 2724 | 2450 | 930 | 2440 | 2450 | 3400 | 1241 | 2220 | 1200-6000 |
| Time of evaluation after BMT | 1y | 16m | 16y | 20y | 7y | 3y | 4y | 1y | |
| Lymphocyte markers (%) | |||||||||
| CD3+ | ND | 60 | 42 | 75 | 74 | 84 | 34 | 22.5 | 51-77 |
| CD4+ | 21 | 39 | 32 | 47 | 36 | 47 | 24 | 18 | 35-56 |
| CD8+ | 23 | 21 | 9 | 26 | 27 | 31 | 20 | 6 | 21-28 |
| CD56+ | ND | 9 | 43 | 12 | 11 | 4 | 23 | 21 | 6-41 |
| CD19+ | 38 | 29 | 13 | 10 | 14 | 8 | 41 | 58.1 | 4-18 |
| TCR Vβ | ND | ND | ND | Normal | Normal | Normal | ND | ND | |
| PHA | ND | 77b | 105,543c | 68b | 69b | 65b | 285a | 307a | |
| TREC (copies/0.5 μDNA) | ND | ND | ND | Normal | Normal | Normal | ND | ND | >400 |
| Serum Ig (g/l) | |||||||||
| IgG | 7.3 | 8.1 | 12.50 | 10 | 8.5 | 7.2 | 7.71 | 8.5 | 2.3-14.1 |
| IgA | 0.13 | 0.65 | 2.47 | 0.9 | 1.5 | 0.4 | 1.51 | 3 | 0-0.8 |
| IgM | 1.38 | 0.84 | 0.8 | 1.5 | 0.9 | 0.5 | 1.19 | 7.5 | 0-1.7 |
| Tetanus (Iu/ml) | ND | ND | Positive | 2.26 | >7 | 3.5 | ND | ND | >0.13 |
| Polio | ND | ND | Positive | 1:64 | ND | ND | ND | ND | >1:16 |
| Isohemagglutinin | ND | ND | 1:32 | 1:128 | 1:64 | 1:02 | ND | ND | >1:64 |
ND: Not Done
a
stimulation index (normal 254-388),
b
% of control stimulation index (Normal >50%),
c
counts per million (Normal >25,000)