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. Author manuscript; available in PMC: 2015 Jul 3.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Sep 27;32(12):2839–2846. doi: 10.1161/ATVBAHA.112.300345

Figure 1.

Figure 1

Characterization of nuclear factor– (erythroid-derived 2) like 2 factor−deficient (Nrf2−/−) peripheral blood mononuclear cells (PBMCs) and bone marrow–derived macrophages (BMDMs). A, Nrf2 mRNA, (B) catalase mRNA, and (C) catalase protein are decreased in PBMCs of Nrf2−/− bone marrow transplantation (BMT) mice. D, Nrf2−/− BMDMs have greater susceptibility to apoptosis and Nrf2 deficiency increases macrophage migration in response to monocyte chemoattractant protein-1 (MCP-1). E and F, Gene expression for Nrf2−/− peritoneal macrophage (PM) treated with lipopolysaccharide (LPS) or vehicle. (Mean±SEM; A–C, n=4–8/group, *P<0.05, **P<0.01 vs. wildtype (WT); D, n=6, †P<0.05, †††P<0.005 vs. WT; E–G, n=3, *P<0.05, ***P<0.005 vs. WT for matched treatment; †P<0.05, ††P<0.01, †††P<0.005 vs. vehicle (Veh) for matched genotype). KO indicates knockout; IL, interleukin.