. Author manuscript; available in PMC: 2015 Jul 3.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Sep 27;32(12):2839–2846. doi: 10.1161/ATVBAHA.112.300345

Table.

WT BMT and Nrf2^−/− BMT Mice Have Similar Metabolic Phenotypes With HFD

	Chow		HFD

	WT (n=5)	Nrf2^−/− (n=4)	WT (n=10)	Nrf2^−/− (n=10)
Body weight, g	26.08 (0.212)	27.98 (0.713)^**	34.94 (1.311)^†††	34.46 (1.400)^†
Body fat, %	8.05 (0.608)	11.82 (2.566)	24.15 (1.304)^†††	25.00 (3.040)^††
Liver fat, %	4.87 (0.730)	2.93 (0.410)	15.35 (1.814)^†††	14.59 (1.859)^††
Fasted glucose, mg/dL	81.00 (7.104)	81.75 (7.510)	93.90 (4.877)	88.30 (5.793)
Fasted insulin, ng/mL	1.00 (0.331)	0.68 (0.148)	1.45 (0.279)	1.41 (0.370)
Triglycerides, mg/dL	261.60 (44.435)	151.59 (25.930)	246.56 (30.361)	269.64 (32.185)^†
Total cholesterol, mg/dL	630.07 (113.86)	436.69 (103.43)	1659.92 (186.70)^†††	1490.52 (156.87)^†
Phospholipids, mg/dL	466.12 (60.665)	337.62 (39.835)	636.51 (33.497)^†	676.95 (35.004)^†

WT indicates wild type; BMT, bone marrow transplant; Nrf2^−/−, nuclear factor− (erythroid-derived 2) like 2 factor deficient; HFD, high-fat diet.

Whereas HFD increased weight, body, and liver fat, cholesterol and phospholipids, they were not different in HFD-fed Nrf2^−/− and WT BMT mice. (Mean±SEM,

^**

P<0.01 vs. WT for matched diet;

^†

P<0.05,

^††

P<0.01,

^†††

P<0.005 vs. chow for matched genotype).