Fig. 3.

Six of 11 candidate compounds are synergistic with MyxV in BT025 cells. Combination index (CI) values for drug-virus interactions were calculated for all 11 compounds based upon multiple dose response curves (Supplementary Fig. S4). CI values were calculated, as described in the Materials & Methods, and plotted as shown. According to the Chou-Talalay method, the interaction is considered synergistic when CI < 1. Six of the 11 drugs interacted synergistically with MyxV. Data are plotted as the mean CI for each combination treatment ± SEM of 2 independent CI calculations.