Fig. 5.

Axitinib demonstrates synergism in 3 additional brain tumor-initiating cell (BTIC) lines. (A) Combination indices (CI) for drug-virus interactions were calculated for axitinib in 3 additional BTIC lines (BT012, BT048, BT073) based upon multiple dose response curves (Supplementary Fig. S6). CI values were calculated as described in the Supplemental Methods. Data are plotted as the mean CI for each combination treatment ± SEM for 2 independent CI calculations.