Table 2 Bootstrap-based Cox regression analyses1 of HTever, showing inclusion frequencies2 (percent) in 1000 bootstrap samples and final selection (yes/no) according to pre-specified criteria.
| Predictor3 | OS (0–5 years, %) | OS (5–10 years, %) | DMFS (0–5 years, %) | LRFS (0–10 years, %) | ||||
|---|---|---|---|---|---|---|---|---|
| 1 There were no selection procedures for DMFS at the second period (5–10 years) because of non-significant result of the likelihood ratio test comparing the base model with the full interaction model. 2 Inclusion frequency may be regarded as a measure of variable importance. 3 The other predictors of the full Cox model (i.e., PR, ER, …, pT) were kept in all bootstrap samples. | ||||||||
| HTever | 100.0 | yes | 100.0 | yes | 99.4 | yes | 100.0 | yes |
| HTever × PR | 76.6 | yes | 38.0 | no | 56.4 | no | 30.5 | no |
| HTever × ER | 70.9 | yes | 86.8 | yes | 32.3 | no | 78.9 | yes |
| HTever × age | 58.8 | no | 77.5 | yes | 77.7 | yes | 31.1 | no |
| HTever × chemotherapy | 49.7 | no | 29.2 | no | 46.6 | no | 17.8 | no |
| HTever × antihormonal therapy | 35.9 | no | 68.9 | no | 26.6 | no | 22.0 | no |
| HTever × grading | 28.7 | no | 23.5 | no | 21.6 | no | 33.5 | no |
| HTever × pN | 28.1 | no | 25.3 | no | 20.2 | no | 42.3 | no |
| HTever × pT | 20.8 | no | 40.2 | no | 67.2 | no | 17.6 | no |