Table III.
Plasma levels of Amino Acids in healthy and asthmatic individuals
| Healthy Controls (n=10) |
Asthma (n=20) |
Asthma based on FENO | ||
|---|---|---|---|---|
| FENO<35ppm (n=9) | FENO≥35ppm (n=9) | |||
| Taurine | 70.4 ± 15.7 | 138.5 ± 11.1* | 150.3 ± 20.6 | 122.5 ± 19.1 |
| Aspartic Acid | 6.8 ± 1.2 | 7.25 ± 0.8 | 7.8 ± 0.9 | 6.6 ± 0.7 |
| Glutamic Acid | 53.9 ± 10.7 | 73.6 ± 7.6 | 72.2 ± 9.2 | 73.4 ± 14.6 |
| Asparagine | 52.5 ± 4.7 | 49.9 ± 2.3 | 51.8 ± 4.6 | 51.1 ± 6.7 |
| Serine | 99.8 ± 8.0 | 89.2 ± 5.6 | 87.4 ± 7.0 | 95.3 ± 8.4 |
| Glutamine | 545.2 ± 17.5 | 527.0 ± 12.4 | 550.4 ± 16.8 | 505.1 ± 15.8 |
| Histidine | 93.6 ± 5.5 | 89.9 ±3.9 | 96.2 ± 5.2 | 88.4 ± 6.3 |
| Glycine | 240.1 ± 24.2 | 221.8 ± 17.1 | 223.4 ± 27.5 | 232.5 ± 30.4 |
| Citrulline | 37.5 ± 3.5 | 28.9 ± 2.5 | 28.9 ± 1.7 | 28.1 ± 3.0 |
| Threonine | 140.0 ± 14.4 | 147.1 ± 10.2 | 155.4 ± 14.1 | 144.1 ± 18.7 |
| Alanine | 391.7 ± 27.7 | 387.7 ± 19.6 | 401.9 ± 28.6 | 382.7 ± 27.1 |
| Arginine | 98.4 ± 11.4 | 101.8 ± 8.0 | 112.7 ± 11.9 | 93.7 ± 14.1 |
| Tyrosine | 64.2 ± 4.8 | 71.0 ± 3.4 | 71.2 ± 3.7 | 73.7 ± 4.4 |
| Amino Butyric Acid | 20.3 ± 1.4 | 16.8 ± 1.0* | 16.4 ± 1.02 | 17.9 ± 1.8 |
| Methionine | 22.5 ± 1.6 | 22.7 ± 1.1 | 21.6 ± 0.7 | 24.6 ± 2.0 |
| Valine | 242.3 ± 12.6 | 229.3 ± 8.9 | 216.7 ± 10.1 | 244.3 ± 8.2# |
| Tryptophan | 49.0 ± 3.1 | 49.5 ± 2.2 | 46.0 ± 3.9 | 54.7 ± 2.8 |
| Phenylalanine | 61.7 ± 3.2 | 61.2 ± 2.3 | 61.6 ± 2.7 | 63.2 ± 2.8 |
| Isoleucine | 72.5 ± 5.8 | 65.3 ± 4.1 | 60.1 ± 4.4 | 71.8 ± 3.1# |
| Leucine | 138.8 ± 9.9 | 125.0 ± 7.0 | 113.8 ± 8.7 | 138.0 ± 5.5# |
| Ornithine | 67.7 ± 7.1 | 70.5 ± 5.1 | 69.9 ± 8.9 | 70.9 ± 6.9 |
| Lysine | 180.8 ± 10.5 | 172.4 ± 7.4 | 177.4 ± 12.7 | 172.7 ± 10.5 |
All data are micromoles/l and mean±SE.
*
p<0.05 between healthy controls and Asthmatics;
#
p<0.05 between asthmatics with low and high FENO.