Figure 3.

Histopathology of intestinal tumor development associated with Blm/BLM in Apc^Min/+ mice. A-F, Although BLM-Tg reduces adenoma numbers on the Apc^Min/+ background, it does not alter the underlying histopathology of emerging adenomas: A, Apc^Min/+ jejunum, boxed area highlights GIN; B, Apc^Min/+;BLM^T/T jejunum, boxed area highlights GIN; C, Apc^Min/+;BLM^T/T cecum, adenoma; D, Apc^Min/+;BLM^+/T colon, adenoma; E, Apc^Min/+;BLM^+/T jejunum, adenoma; F, Apc^Min/+;BLM^T/T ileum, adenoma. G-H, Blm haplo-insufficiency drives tumor development and accelerates the development of intestinal adenomas with high-grade dysplasia and invasive carcinoma: G, Apc^Min/+;Blm^Cin/+, adenoma with high-grade dysplasia; H, Apc^Min/+;Blm^Cin/+, invasive adenocarcinoma. All sections were stained with hematoxylin and eosin. Scale bars each represent 100 μm.