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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Jun 8;39(7):1166–1173. doi: 10.1111/acer.12766

Table 3.

Hazard Ratios and (95% Confidence Intervals) from Cox Proportional Hazards Regression Models of First DSM-IV Alcohol Dependence Symptom from First Standard Drink of Alcohol

Predictor (risk period) Model I Model II Model IIIa
Risk Group
1. Father DD or AD 1.20 (1.02 – 1.41) 1.22 (1.03 – 1.43) 1.19 (1.01 – 1.41)
2. Father unaffected, MZ uncle DD or AD 1.30 (1.04 – 1.64) 1.31 (1.04 – 1.65) 1.36 (1.09 – 1.71)
3a. Father unaffected, DZ uncle DD 0.95 (0.72 – 1.26)
1.19 (0.95 – 1.48)

1.18 (0.94 – 1.48)
3b. Father unaffected, DZ uncle AD 1.36 (1.03 – 1.78)
4. Father and uncle unaffected (referent group) 1.00 1.00 1.00
Parental separation -- 0.89 (0.77 – 1.03) 0.81 (0.68 – 0.95)

Note. DD= drug dependent; AD = alcohol dependent. Differences between Risk Groups 1–3 non-significant except Model I, Risk Group 2>3a and 3b>3a, p < 0.05.

a

Controlling for maternal AD and history of cannabis use, offspring sex and birth cohort, family income, mother report of offspring inattention, hyperactivity and oppositional defiant disorder, and offspring self-report of conduct disorder, depression, suicidality, social phobia, generalized anxiety disorder, panic attacks, childhood trauma, childhood physical abuse/neglect and childhood rape/molestation, and age at first standard drink of alcohol. See Supplementary Table 2 for individual hazards.

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