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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Jun 8;39(7):1166–1173. doi: 10.1111/acer.12766

Table 4.

Hazard Ratios and (95% Confidence Intervals) from Cox Proportional Hazards Regression Models of DSM-IV Alcohol Dependence Diagnosis from First Standard Drink of Alcohol

Predictor (risk period) Model I Model II Model IIIa
Risk Group
1. Father DD or AD 1.58 (1.11 – 2.24) 1.62 (1.14 – 2.30) 1.59 (1.09 – 2.32)
2. Father unaffected, MZ uncle DD or AD 1.54 (0.96 – 2.46) 1.55 (0.97 – 2.47) 1.79 (1.07 – 2.98)
3. Father unaffected, DZ uncle DD or AD 0.92 (0.55 – 1.54) 0.94 (0.56 – 1.57) 1.04 (0.60 – 1.81)
4. Father and uncle unaffected, 1.00 1.00 1.00
Parental separation -- 0.82 (0.61 – 1.11) 0.65 (0.46 – 0.92)

Note. DD= drug dependent; AD = alcohol dependent. Differences between Risk Groups 1–3 non-significant except Models I and II, Risk Group 1 > 3, p < 0.05.

a

Controlling for maternal AD and history of cannabis use, offspring sex and birth cohort, family income, mother report of offspring inattention, hyperactivity and oppositional defiant disorder, and offspring self-report of conduct disorder, depression, suicidality, social phobia, generalized anxiety disorder, panic attacks, childhood trauma, childhood physical abuse/neglect and childhood rape/molestation, and age at first standard drink of alcohol. See Supplementary Table 3 for individual hazards.

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