Table 3.

Meta-analysis of interactions between FADS1 SNPs (rs174548 and rs174538) and dietary fatty acids in association with circulating omega-3 fatty acids, stratified by fatty acids measurement compartment

Interactions between dietary ALA X rs174548 for plasma omega-3 fatty acids					Interactions between dietary ALA X rs174548 for erythrocyte omega-3 fatty acids
	β	SEM	P	β direction	β	SEM	P	β direction	P*
EPA	−0.0118	0.010	0.223	−−+−+	0.018	0.012	0.120	+−++	0.048
DPA	−0.010	0.004	0.006	−−−−	0.034	0.017	0.048	++++	0.012
DHA	−0.036	0.021	0.085	−−−−+	0.13	0.05	0.005	++++	0.001
Interactions between dietary LA X rs174548 for plasma omega-3 fatty acids					Interactions between dietary LA X rs174548 for erythrocyte omega-3 fatty acids
EPA	−0.0008	0.001	0.408	+−+−+	0.002	0.001	0.151	+−++	0.103
DPA	−0.001	0.001	0.057	+−−−	0.004	0.002	0.014	++++	0.004
DHA	−0.004	0.002	0.106	+−−−+	0.011	0.004	0.009	++++	0.002
Interactions between dietary ALA X rs174538 for plasma omega-3 fatty acids					Interactions between dietary ALA X rs174538 for erythrocyte omega-3 fatty acids
	β	SEM	P	β direction	β	SEM	P	β direction	P*
EPA	−0.0135	0.010	0.183	−−+−+	0.010	0.011	0.400	+−++	0.189
DPA	−0.010	0.004	0.007	−−−−	0.024	0.017	0.146	++−+	0.043
DHA	−0.046	0.022	0.033	−−−−+	0.096	0.05	0.041	+−++	0.006
Interactions between dietary LA X rs174538 for plasma omega-3 fatty acids					Interactions between dietary LA X rs174538 for erythrocyte omega-3 fatty acids
EPA	−0.0009	0.001	0.360	−−+−+	0.001	0.001	0.432	+−−+	0.235
DPA	−0.001	0.001	0.059	+−−−	0.003	0.002	0.074	++−+	0.025
DHA	−0.006	0.002	0.017	−−−−+	0.009	0.005	0.037	+−++	0.003

β represents the difference in the magnitude of the dietary fatty acids association with circulating fatty acids (expressed as difference in circulating fatty acid per 1 gram/day greater intake of fatty acid) per copy of the effect allele

P =P value for meta-analysis of interactions between SNP X dietary fatty acids for the outcome of circulating fatty acids

P* =P value for association between fatty acids compartment for the interaction of dietary fatty acid X SNP on circulating fatty acid.

For EPA and DHA in the plasma compartment the cohort order =ARIC, CARDIA, CHS, InCHIANTI, MESA

For DPA the plasma compartment the cohort order =ARIC, CARDIA, CHS, MESA

For EPA, DPA and DHA in the erythrocyte compartment the cohort order =GOLDN, HPFS, NHS, WGHS

ALA, alpha linolenic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid, LA, linoleic acid