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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: J Immunol. 2015 Jun 5;195(2):717–725. doi: 10.4049/jimmunol.1401250

Fig. 6. HY-specific iTregs are highly stable under inflammatory conditions.

Fig. 6

Male or Female BDF1 mice were lethally irradiated and transferred with TCD-BM alone or plus 4 x 106/mouse CD25-depleted total T cells from normal B6 Ly5.1+ donors. HY-specific iTregs were also transplanted at 2 x 106/mouse on day 0 of BMT. On days 7, 14, and 21 post BMT spleen (A, C) and liver (B, D) were collected from recipient mice for analysis. Phenotypes of cells isolated from recipient spleen (A) or liver (B) are displayed. Absolute numbers of originally infused iTregs (H2Kb+CD4+Vβ6+) in spleen (C) or liver (D) are depicted on the left panels. Percentages of Foxp3 expression on gated iTregs in spleen (C) or liver (D) were shown on the right panels. Asterisk indicates statistical significance: *p<0.05, **p<0.01, ***p<0.001.