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Hypothetical schematic model: CDK5 RNAi-induced protection and cognitive improvement in a pathological context that depended on the p35/Rac1 GTPase pathway. CDK5 shRNAmiR blocks calpain activation and the cleavage of p35 to p25 produced by glutamate, which generates neuroprotection in a p35 up-regulation dependent-mode and its down-stream control of Rho GTPases, such as Rac1 and RhoA.
