Figure 8.

Eos^−/− CD4⁺ T cells secrete high amounts of IL-17 in the CNS of chimeric mice. (A) Clinical score of EAE in chimeric mice. BM chimeras were generated (WT+WT, and WT+Eos^−/−) using congenic markers, and 6 wk after reconstitution, EAE was induced in mice as in Fig. 7. (B) Percentage of CD4⁺ T cells in the spinal cord and spleen of chimeric mice. (C) and (D) Percentage of CD4⁺Foxp3⁺ Treg in the CNS of chimeric mice. (E) Percentage of IFN-γ⁺, IL-17⁺ and double positive cells in the spinal cord of chimeric mice.