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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: J Immunol. 2015 Jun 3;195(2):611–620. doi: 10.4049/jimmunol.1500112

FIGURE 3.

FIGURE 3

Exogenous PC-specific antibody in B cell-deficient mice partially protects against infection. B cell deficient mice (µMT) were infected with PC and then given twice-weekly injections of serum either from infected C57BL/6 donors or from infected µMT donors (A, C, E) or were infected with PC pre-opsonized with antiserum from infected C57BL/6 or µMT donors (B, D, F). (A, B) PC lung burden was assessed in lung digest samples and expressed as Log10 PC organisms per lung. (C, D) T cells were identified by CD4 staining using flow cytometry and enumerated in the BALF, digested lung, and TBLN. (E, F), Concentrations of IFNγ and TNFα in the BALF were assessed by ELISA. Data are presented as mean ± SD for groups of 5 mice per timepoint per group. Statistical significance defined at a p-value of < 0.05 for data compared to WT mice at each timepoint (*).