Table 1.

Candida biofilm growth conditions	Biofilm architecture	Dual biofilm biovolume	Tissue invasion and damage
Wet	Long intertwined hyphae forming a homogeneous surface biofilm	+ + +	+
Wet, plus S. oralis	S. oralis formed a biofilm mat adjacent to the mucosa under C. albicans	+ + + +	++
Semi-dry	Localized foci of dense hyphal growth	+ + +	+ + +
Semi-dry, plus S. oralis	S. oralis in close physical proximity with hyphae within foci	+ + +	+ + + +
Semi-dry, plus S. oralis, 5% BHI	S. oralis in close physical proximity with hyphae within foci	+ + + +	+ + + + +
Semi-dry, plus S. oralis, 10% BHI	S. oralis in close physical proximity with hyphae within foci	+ + + + +	+ + + + + +