Table 2.

Strain/Hyphal morphotype	Dual biofilm architecture	Dual biofilm biovolume	Tissue invasion and damage
Wild type/hyphae	S. oralis in close proximity to hyphae, interspersed throughout the thickness of the biofilm	+ + + + +	+ + + + + +
ndt80 +/+/hyphae	S. oralis in close proximity to hyphae. Interspersed throughout the thickness of the biofilm	+ + + + +	+ + + + + +
ndt80−/−/pseudohyphae	Most S. oralis cells localized adjacent to the mucosal surface, some also co-aggregated with pseudohyphae	+ +	C. albicans only + C. albicans+S. oralis + + +
tup1−/−/pseudohyphae	Most S. oralis cells localized adjacent to the mucosal surface, some also co-aggregated with pseudohyphae	+ +	C. albicans only + C. albicans+S. oralis + + +