Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 17;6(7):504–517. doi: 10.1007/s13238-015-0181-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Binding of flavonoids to Mtb HadAB complex. (A) K _D values determined for the binding of flavonoids to MtbHadAB complex by ITC. (B) Different flavonoids tested in the current study (shown as sticks) bind at the same location on MtbHadAB. Upon superimposition of the structures, the ligands overlap. They bind in the cavity (right panel, gray colored surface representation) located just beneath the fatty acid binding channel. An example of butein (BUN; cyan sticks, right panel) bound in the cavity is shown. (C) Nature of amino acid interacting with flavonoids is shown. Flavonoids and amino acids are shown as sticks, while water is depicted as spheres. 2Fo-Fc electron density contoured at 1σ for the three ligands is shown