Skip to main content
. Author manuscript; available in PMC: 2016 Jul 2.
Published in final edited form as: Cell. 2015 Jul 2;162(1):211–220. doi: 10.1016/j.cell.2015.05.054

Figure 4.

Figure 4

working model compatible with the localized interaction observed in Fig. 2-3. When β-actin mRNA is in the perinuclear region, ZBP1 interacts with the mRNA to repress its translation. When the mRNA reaches the leading edge of the fibroblast (A), it releases ZBP1 and translates more actively. In the soma of neurons, ZBP1 binds more effectively to β-actin mRNA in the perinuclear region (B) than in the fibroblast, likely to assemble the mRNA into granules and inhibit translation more completely until the mRNA is transported to dendrites ((Buxbaum et al., 2014)).