Table 5.
Association of preterm birth and smoking with maternal cerebrovascular event (n = 1,848)
| Univariate | Multivariate 1 | Multivariate 2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95 % CI | HR | 95 % CI | HR | 95 % CI | ||||
| Term birth | Ref | Ref | Ref | ||||||
| Any preterm birth | 1.94 | 1.69 | 2.23 | 1.81 | 1.56 | 2.09 | 1.68 | 1.46 | 1.95 |
| Preterm birth by severity | |||||||||
| Late preterm birth | 1.68 | 1.39 | 2.03 | 1.58 | 1.31 | 1.91 | 1.49 | 1.23 | 1.80 |
| Moderately preterm birth | 2.20 | 1.64 | 2.97 | 2.07 | 1.54 | 2.78 | 1.90 | 1.41 | 2.56 |
| Extremely preterm birth | 2.45 | 1.90 | 3.16 | 2.32 | 1.75 | 3.07 | 2.13 | 1.61 | 2.82 |
| Preterm birth by onset | |||||||||
| Spontaneous preterm birth | 1.63 | 1.36 | 1.95 | 1.60 | 1.34 | 1.92 | 1.49 | 1.24 | 1.78 |
| Indicated preterm birth | 2.63 | 2.13 | 3.24 | 2.25 | 1.80 | 2.81 | 2.12 | 1.70 | 2.65 |
| Preterm birth by number | |||||||||
| 1 preterm birth | 1.90 | 1.64 | 2.20 | 1.79 | 1.54 | 2.08 | 1.68 | 1.44 | 1.95 |
| ≥2 preterm births | 2.43 | 1.58 | 3.73 | 1.99 | 1.28 | 3.07 | 1.76 | 1.14 | 2.73 |
| Smokinga | |||||||||
| Never smoking during pregnancy | Ref | Ref | |||||||
| Smoking before last pregnancy | 2.08 | 1.68 | 2.57 | 1.72 | 1.38 | 2.14 | |||
| Smoking during last pregnancy | 2.18 | 1.98 | 2.41 | 2.04 | 1.84 | 2.27 | |||
Multivariate 1: Preterm birth adjusted for maternal age at delivery, country of birth, socioeconomic status, number of births, SGA, pregestational and gestational diabetes
Multivariate 2: Variables in Multivariate 1 + maternal smoking during pregnancy
a: Multivariate 2 adjusted for any preterm birth