Table 5.
Expression levels of 4 genes required for miRNA biogenesis in breast tissues
| Breast tissue | ER+/ER− | ER+/Normal | ER−/Normal | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | Normal (n = 8) | ER+ (n = 85) | ER− (n = 68) | FC | p-value | FC | p-value | FC | p-value |
| DICER1 | 1.0 | 0.92 | 0.50 | 1.85 | <0.0001 | −1.09 | ns | −2.00 | 0.0004 |
| (0.79-1.36) | (0.05-3.18) | (0.10-1.94) | |||||||
| DROSHA | 1.0 | 1.27 | 0.77 | 1.65 | <0.0001 | 1.27 | ns | −1.30 | 0.0486 |
| (0.77-1.56) | (0.08-4.91) | (0.09-6.37) | |||||||
| DGCR8 | 1.0 | 1.05 | 0.72 | 1.46 | <0.0001 | 1.05 | ns | −1.39 | 0.0506 |
| (0.78-1.56) | (0.19-4.77) | (0.13-3.44) | |||||||
| AGO2 | 1.0 | 0.80 | 1.10 | −1.37 | 0.0433 | −1.25 | ns | 1.10 | ns |
| (0.56-1.10) | (0.17-3.74) | (0.08-4.74) | |||||||
Results in ER+ and ER− breast tumors are expressed as the median (range) of level relative to normal breast tissues. For each comparison, we report the fold-change (FC) and the p-value associated to Mann-Whitney’s test (ns for not significant)