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. 2015 Jul 4;22(1):48. doi: 10.1186/s12929-015-0150-2

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© Kawai et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Association between phosphorylation status of Histone H3 Ser10 and viability of midostaurin treated cells in breast cancer cell lines. The phosphorylation of Histone H3 Ser10 and Histone H3 in breast cancer cell lines was semi-quantified by densitometry after Western blot analysis. The phosphorylation level is determined as a ratio of the value of the phosphorylation at Ser10 against that of the total protein of Histone H3 and indicated as p-Histone H3/Histone H3. The values are shown in as relative to MDA-MB-468 cell. a The association of the phosphorylation level of Histone H3 Ser10 with cell viability after the midostaurin treatment. Pearson’s correlation coefficient: −0.51, p = 0.021 by Pearson correlation test. b Box plot showing the phosphorylation level of Histone H3 Ser 10 among the breast cancer subtypes